It is very difficult to see that all six hepatitis B items are positive in clinical practice. The six hepatitis B items contain three pairs of antigen antibodies, only two pairs are complete, but as long as a pair of antigen antibodies are positive at the same time, it is very difficult to be positive at the same time. The hepatitis B surface antigen and surface antibody, the surface antigen is the small particles in the blood that replicate the most after the hepatitis B virus infects the body; the hepatitis B surface antibody is a protective antibody that neutralizes the hepatitis B surface antigen in the blood, it is not common for both to appear positive at the same time, the same is true for the hepatitis B e antigen and e antibody, it is difficult to appear positive at the same time. If they do appear to be positive at the same time, they should be reviewed periodically, and the review should be quantitative, so that the trend in the value of each antigen and antibody can be observed; if the test is only qualitative, only negative or positive results will be obtained, and the trend cannot be observed. If the six hepatitis B tests are all positive, it is important to see what the quantification is after a period of time, and generally only one antigen or antibody will remain positive, and not both at the same time.