The degree of pain in appendicitis cannot be generalized and is related to the type of appendicitis, its severity, and individual tolerance level. If it is simple chronic appendicitis, the metastatic right lower abdominal pain may not be obvious, mostly dull pain, or even just a slight abdominal distension; suppurative or gangrenous appendicitis is mostly persistent severe pain; peritonitis occurs when the appendix is perforated, it can show severe cutting pain and accompanied by the expansion of the scope of pain. Individuals have different tolerances, so the pain is not always the same. The pain of appendicitis is similar to that of cholecystitis, right-sided ureteral stones and bowel perforation, but there are points of differentiation. Cholecystitis will have a positive Murphy’s sign (deep inhalation followed by thumb pressure on the gallbladder area and exhalation with gallbladder pressure), ureteral stones are colicky and intense in nature, and bowel perforation often has a history of being more difficult to differentiate. When appendicitis is suspected, it is necessary to actively seek medical attention and follow the doctor’s instructions for rational treatment.