Mixed bone lesions of nasopharyngeal cancer usually need to combine radiotherapy, chemotherapy, bone-modifying drugs, surgery and other treatments for comprehensive treatment. Mixed bone lesions of nasopharyngeal cancer may be the result of bone metastasis of cancer cells, which is usually in the advanced stage of nasopharyngeal cancer, and the treatment is more complicated, and comprehensive treatment is needed to control the spread of the tumor and alleviate the pain of patients. Radiotherapy usually adopts IMRT (Intensity Modulated Radiotherapy Technology), which concentrates the radiotherapy dose in the target area to kill tumor cells and reduce the damage to adjacent tissues. The common chemotherapeutic drugs include paclitaxel, gemcitabine, doxorubicin, cisplatin, 5-fluorouracil, etc., which can play a role in stopping the proliferation, infiltration and metastasis of cancer cells. Patients with bone lesions can also use drugs such as bisphosphonates to delay bone destruction, reduce patients’ bone pain and improve their quality of life. For bone metastasis causing severe bone destruction, bone cementoplasty can be performed for treatment. The specific treatment plan needs to be decided according to the patient’s own situation, and it is recommended that the patient actively cooperate with the doctor’s treatment.