What does DNA ploidy mean?

DNA ploidy refers to the number of ploidy of the genetic material DNA. Normal human somatic cells in resting phase all have 23 pairs, 46 chromosomes in total, and the DNA of the genetic material on each chromosome has an identical backup, i.e. allele. In other words, normal human somatic cells are diploid in non-dividing conditions. In some disease states, such as patients with malignant tumors, the appearance of polyploidy such as hyperdiploidy, triploidy, and even tetraploidy and octoploidy is the abnormality of DNA ploidy due to the abnormal DNA content of tumor cells. Therefore, DNA ploidy analysis is often applied clinically for early detection of malignant tumors. However, it should be noted that some chronic inflammatory diseases causing cell fusion can also occur with DNA ploidy abnormalities.