Intercostal neuralgia, esophageal lesions, cardiac lesions, pleurisy, etc. can be seen in the middle of the upper chest. 1. Intercostal neuralgia: Intercostal neuralgia can appear in the middle of the upper chest, which is commonly caused by staying up late, stress, fatigue, etc. Adjusting the daily routine and supplementing vitamin B can relieve it. 2. Esophageal lesions: the esophagus passes from the back of the sternum, if there is a lesion in this section of the esophagus, the pain in the esophagus can make the patient feel the pain in the chest, such as esophagitis, esophageal tumors and so on. 3. Heart disease: when heart disease, such as angina pectoris, myocardial infarction, there can be pressure-like pain in the forehead. Further ECG, cardiac ultrasound and other related examinations are needed to confirm the diagnosis. 4. Pleurisy: pleura covers the surface of chest wall and lungs, when there is inflammation of pleura, pain in the forehead can also occur. There are many reasons for the pain in the middle of the upper chest, it is recommended to go to the hospital to complete the relevant examinations, find the cause of the disease and symptomatic treatment, and should not blindly use medication on their own.