Alcohol should be avoided during treatment with cephalosporins, and patients should drink moderately only about 1 week after the end of treatment. The metabolism of cephalosporin in human body takes some time, generally it takes 72 hours or even longer for the body to completely metabolize after taking cephalosporin. If you drink alcohol during this period, cephalosporins and alcohol will have a disulfiram reaction, which can cause difficulties in acetaldehyde metabolism in the human body and cause acetaldehyde poisoning. Patients may experience adverse reactions within 1-2 hours, such as flushing, chest tightness, shortness of breath, vomiting, increased heart rate, decreased blood pressure, and in severe cases, respiratory distress and cardiac arrest. As each person’s body quality is different, the ability to metabolize cephalosporin is also different. Generally, the chance of adverse reactions is highest on the first day and decreases subsequently, and the drug is usually metabolized completely within 1 week. In addition, during the period of abstinence, patients are advised to drink more water to speed up the metabolism of cephalosporin, and to seek medical consultation as soon as uncomfortable symptoms appear.