Severe neonatal pulmonary hypertension is very dangerous. Neonatal pulmonary hypertension refers to the development of persistent pulmonary hypertension in newborns. As the pressure in the pulmonary arteries continues to increase, it may cause the newborn’s heart to develop a right-to-left blood shunt at the level of the atria or at the level of the ductus arteriosus. If not relieved in time, this may lead to the development of severe hypoxemia and may even be life threatening. If the newborn has pulmonary hypertension for a long period of time, it can lead to an increase in the load on the heart. This may lead to heart failure over a long period of time. Therefore, when there is pulmonary hypertension in newborns, it is necessary to actively carry out treatment, and find the cause of the disease and take different treatment programs.