Squatting toilet up knee pain may be related to neurovascular compression, strain, joint inflammation and so on. 1. Neurovascular compression: squatting toilet time is too long, can lead to the knee joint around the nerves, blood vessels are under pressure, affecting the surrounding tissues caused by knee pain, numbness and so on. 2. Strain: long-term squatting, mountaineering and other activities can lead to meniscus, muscles, ligaments and other soft tissue injuries, long-term injuries lead to soft tissue strain, squatting toilet will cause knee pain. 3. Joint inflammation: when patients have rheumatoid arthritis, gouty arthritis, septic arthritis and other inflammatory lesions, can lead to squatting toilet after knee pain and other symptoms. Squatting toilet up knee pain has a variety of reasons, it is recommended to go to the hospital in a timely manner, improve the relevant examination for active treatment.