The Hoffman sign is a medical physical examination, named after the Hoffman people by foreigners. During the Hoffman sign examination, the examiner puts his left hand on the wrist of the examinee, gently clamps the end of the patient’s middle finger with his right index and middle fingers, and slightly dorsiflexes the wrist joint so that each finger is lightly flexed, and quickly scrapes the nail of the examinee’s middle finger with the thumb. There should be no reaction when normal. If the thumb of the patient is inwardly retracted and the other fingers are also flexed, it is called a positive Hoffman’s sign. The significance of positive Hoffman’s sign: It is a pathological reflex, representing injury or lesion of the cone bundle of the upper limbs, commonly seen in cerebrovascular disease and also in cervical spondylosis. If the Hoffman’s sign is positive bilaterally without neurological signs, it has no localization significance and belongs to the neurological examination.