In the treatment of essential hypertension, indapamide and nifedipine extended-release tablets can be used in combination. However, this drug combination is not suitable for all patients and is recommended to be used under the guidance of a professional doctor. 1. Indapamide: commonly used dosage forms include tablets and capsules. It is an anti-hypertensive drug used for the treatment of adult essential hypertension. Adverse effects of the drug include hypokalemia, hyponatremia, elevated blood uric acid and blood glucose, allergic skin reactions, nausea, constipation, dizziness, fatigue, headache and dry mouth. Contraindications to the drug are: it is contraindicated in patients with hypersensitivity to sulfonamide, severe renal insufficiency, hepatic encephalopathy, hypokalemia. It is forbidden to combine this product with lithium and non-antiarrhythmic drugs that can provoke torsional ventricular tachycardia. Use with caution in athletes. 2. Nifedipine extended-release tablets: calcium antagonist. It is used in the treatment of chronic stable angina pectoris, vasospastic angina pectoris and essential hypertension. The adverse reactions of this drug include headache, red face, redness, swelling and pain of upper and lower limbs, panic, edema of lower limbs, dizziness, fatigue, gingival hyperplasia and so on. Contraindications to the drug include hypersensitivity to nifedipine and other components of the product, patients with severe aortic stenosis, patients with unstable angina, patients with recent myocardial infarction (within the last 4 weeks), patients taking rifampicin, pregnant women and other contraindications. It can be seen that in the treatment of essential hypertension, indapamide and nifedipine extended-release tablets can be used in combination, the two not only have no contraindications, but also can enhance the effect of lowering blood pressure. Indapamide and nifedipine extended-release tablets should be used under the guidance of a professional doctor, and should not be used blindly on their own to avoid adverse reactions.