Knee joint effusion is often characterized by swelling and pain in the knee joint and unfavorable movement, which belongs to the categories of “paralysis” and “crane’s knee wind” in Chinese medicine. Gui Zhi Pao Yao Zhi Mu Tang can treat knee joint effusion caused by wind-cold-damp paralytic obstruction. Knee joint effusion is mainly manifested by swelling and pain of the knee joint and unfavorable movement, which belongs to the categories of “paralysis” and “crane’s knee wind” in Chinese medicine. The cause of the disease is mostly trauma and fatigue, chronic illness and physical weakness, living in a damp place for a long time, resulting in wind, cold, dampness and heat of the evil invasion of the body, stay in the joints, resulting in paralysis of the blood, not through the pain; or insufficient qi and blood, loss of nourishment of the tendons and bones, not glory is pain. Chinese medicine clinics can categorize this disease into cold-damp paralysis, damp-heat paralysis, deficiency of liver and kidney (weak function of liver and kidney), deficiency of qi and blood, and blood stasis paralysis. Gui Zhi Pao Yao Zhi Mu Tang is composed of Gui Zhi, Paeoniae Alba, Zhi Mu and Radix et Rhizoma Gastrodiae. Its main effects include promoting Yang circulation and paralysis, dispelling wind and expelling dampness, harmonizing the camp and relieving pain. It treats wind-cold-dampness paralysis (paralysis of limbs caused by wind, cold and dampness), swelling and pain in joints of limbs, physical weakness, dizziness and shortness of breath. Therefore, it has some therapeutic effect on knee joint effusion caused by wind-cold-damp paralysis. The adverse reactions and contraindications of this drug are not clear. It is recommended to use the drug under the guidance of a doctor. If the symptoms are serious, it is recommended to consult a doctor in time and follow the doctor’s instructions to use the medicine, do not take the medicine by yourself.