There is no best and fastest drug for lumbar disc herniation in the acute stage, and it is necessary to choose the appropriate one according to the individual situation. The drugs include non-steroidal anti-inflammatory and analgesic drugs, nutritive nerve, muscle relaxant drugs and dehydrating agents. 1. Non-steroidal anti-inflammatory and analgesic drugs: When pain is the main cause, ibuprofen and diclofenac sodium can be taken orally if there are no contraindications. 2. Nutritional nerve: localized lower limb nerve pulling pain and numbness, can use methylcobalamin, vitamin B complex, etc.. 3. Muscle relaxants: used when accompanied by muscle spasms, such as chlorzoxazone, flupirtine, etc. 4. Dehydration agent: can be used when considering nerve edema, such as mannitol. If you are in the acute stage of lumbar intervertebral disc herniation, it is recommended to go to the hospital in a timely manner, under the guidance of the doctor for standardized treatment, the above drugs need to be taken in accordance with medical advice.