Toes grinding up hard skin is very painful is mostly caused by friction caused by tissue damage or corns, you can choose physical therapy, drug therapy or surgical treatment according to different causes. 1. Tissue damage: (1) Physical therapy: long-term friction of the toes by extrusion can cause pain, can be localized ice packs, contraction of blood vessels to reduce sensation and relieve pain. (2) medication: if there is no obvious effect of physical therapy, you can follow the doctor’s instructions to take acetaminophen, ibuprofen and other analgesic drugs to achieve the purpose of pain relief, and usually pay attention to rest to avoid re-injury to the affected area. 2. Chicken eye: It is a keratosis damage that occurs when the skin of the foot is extruded or rubbed for a long time, and the pain is its typical clinical manifestation. Pain is the typical clinical manifestation. At this time, it is necessary to treat the cause of the disease in order to relieve the pain. (1) medication: you can use corns cream, 10% ~ 15% salicylic acid ointment, 40% urea ointment and other drugs coated in the affected area, regular drug change, each time before the change of the drug is also needed to remove the residual powder after soaking the foot in hot water and scraping off the softened keratin. (2) Surgical treatment: corns are usually treated with non-surgical treatment first, and then surgically removed after it is ineffective. The doctor first gives the patient local anesthesia and then uses a scalpel to dig out the corns along the edge of the corns plugs, and then bandages them with sterilized gauze. Toes grinding up hard skin is very painful may also be seen in other causes, if the symptoms can not be relieved or even aggravated phenomenon, it is recommended to consult a doctor in a timely manner, to clarify the cause of the disease for professional treatment, do not unauthorized use of medication.