Itchy and peeling nipples are mostly considered to be caused by eczema, which needs to be treated with appropriate medications, such as glucocorticoids and calcium-modulated phosphatase inhibitors, for the specific disease. Eczema occurs in the nipple, can cause nipple itching, peeling skin, red rash, papules, pimples, vesicles and other symptoms. Treatment can be topical glucocorticoid therapy such as hydrocortisone cream; or topical calcium-modulated phosphatase inhibitor therapy such as pimecrolimus and tacrolimus. If the itching is severe, oral antihistamine treatment, such as loratadine, cetirizine and so on. Patients are advised to pay attention to the hygiene and cleanliness of nipples and breasts. Go to the regular hospital in time, after clarifying the cause of the disease, targeting treatment. When using medication, strictly follow the doctor’s instructions to use medication, not blindly self-medication.