Taking a particular drug for a long time may lead to drug tolerance, which means that the efficacy of the drug is affected. If you take antibiotics for a long time, it is easy to lead to bacterial resistance, and the antibacterial effect of antibiotics decreases, and the infection is not controlled. So drugs like antibiotics are not recommended for long-term use and must be used according to a strict dosage and regimen. Also, antibiotics should be changed regularly to avoid resistance. In addition, like antihypertensive, hypoglycemic drugs long-term use, as long as the drug effect is not affected, and no adverse drug reactions, can be long-term use. If there is drug resistance or more serious adverse drug reactions can not be tolerated, only then should you consider to replace other drugs.