Glomerulosclerosis is a pathomorphologic feature of glomerular lesions and is a late manifestation of the progression of various renal diseases. Glomerulosclerosis lesions are characterized by sclerotic changes occurring in glomerular capillary collaterals, which is a late manifestation of a variety of kidney diseases, including hereditary nephritis, IgA nephropathy, diabetic nephropathy, obstructive nephropathy, lupus nephritis, and renal damage of hypertension, etc. The patient may have proteinuria, hematuria, which may be accompanied by hypertension and impaired renal function. If glomerulosclerosis occurs, patients should take relevant treatment. Nutritional maintenance and support should be paid attention to in daily life, and hormones and immunosuppressive drugs, such as prednisone and cyclophosphamide, can be used under the guidance of doctors to slow down the progress of the disease. If patients are found to have glomerulosclerosis, it is recommended to go to regular hospitals in time and standardize the treatment under doctors’ guidance.