Patients with advanced cholangiocarcinoma are dying due to multiple organ failure, such as liver and kidney failure. Patients with advanced cholangiocarcinoma have varying degrees of jaundice, and when combined with cholangitis, they may also experience severe pain in the right upper abdomen, chills and high fever, jaundice, and even shock. Portal hypertension can lead to bleeding from the upper elimination tract, and advanced patients also tend to develop hepatorenal syndrome with oliguria and anuria. In patients with jaundice, percutaneous hepatic puncture, bile duct placement for drainage or placement of internal stents, transendoscopic nasal catheter drainage or placement of internal stents, along with liver protection, liver protection, and symptomatic treatment with plasma, concentrated red blood cells, and human albumin can be used. In case of cholangitis, anti-infective treatment with sensitive antibacterial drugs should also be administered. In addition, for patients with significant pain, morphine or pethidine can be applied for pain relief.