The brain controls and governs the behavior of the human body, and when there is a problem with the brain, the whole body will be involved. Skull defect is a very common disorder nowadays, the skull is like a helmet for the brain tissue, it protects the human brain, but if the skull is defective, then the intracranial tissue will be attacked by the outside world, causing more problems. Therefore, when cranial defects occur, we should not be careless and go to the hospital for examination and treatment in time. The more effective way to solve the problem of cranial defects is to do cranial bone repair surgery. When to do cranial bone repair when both sides of the skull are removed? The timing of the skull repair surgery is something that needs to be taken seriously, and it is more helpful when the timing is right. Generally speaking, for those open skull crush patients with better wound cleaning and no intracranial hypertension, they can perform cranial bone repair surgery in one phase; however, if they belong to patients with severe closed cranial trauma and skull defects caused by bilateral removal of skull due to intracranial hypertension, then generally they should do cranial bone repair surgery about three months after surgery. The timing of cranial repair surgery is very important, and the choice of repair material should not be too casual. Nowadays, titanium mesh material is widely used, but according to a large number of clinical treatment verification, titanium mesh material still has certain defects and shortcomings, some patients have some problems after surgery, and the surgery faces failure, so it is not an ideal choice. The PEEK material used by our team is very good, which is a new type of polymer material, and it has advantages over titanium mesh material, with excellent performance in all aspects. In addition, we have introduced the concept of aesthetic plastic surgery in the procedure, and the clinical treatment has achieved very good results and has been trusted and recognized by the majority of patients.