Levofloxacin can be taken if the toothache is caused by inflammation of the teeth and surrounding tissues, but it should not be used due to neurological disorders or involved pain such as angina pectoris originating from diseases of distant organs. Levofloxacin is a quinolone antimicrobial drug, mainly used for the treatment of sensitive Gram-negative and Gram-positive bacteria causing infections of the oral cavity, urinary system, digestive system, ear, nose and throat and other parts of the body. If the toothache is caused by oral inflammation, then it is possible to take levofloxacin, if it is due to other causes including neurological diseases or distal organ diseases brought about by involving pain, should be directed to the cause of treatment. Toothache patients should consult a doctor in time, if necessary, can take painkillers such as ibuprofen, celecoxib and other drugs, should go to the regular hospital stomatology department for examination, in order to clarify the cause of toothache, under the guidance of the doctor for treatment, pay attention to oral hygiene in daily life, the use of drugs need to comply with the doctor’s instructions.