Urine protein 2+, occult blood 1+, decreased glomerular filtration rate may be acute renal failure or chronic renal failure. Whether immunization is possible should be determined by the patient’s condition. If the patient’s condition is stable, he/she can usually take vaccination; if the patient is in the active stage of the disease, vaccination is not suitable for the time being. Regardless of whether the patient is in acute renal failure or chronic renal failure, if the patient’s condition is under good control, with no obvious clinical symptoms, stable blood pressure and blood glucose control, and no infections, he/she can take vaccinations. If the patient’s condition is unstable, combined with difficult to control high blood pressure, abnormal blood sugar, infection, heart failure, edema, large amount of proteinuria, hematuria of the naked eye, etc. or allergic to the vaccination, it is not suitable for vaccination. When the patient has the phenomenon of urine protein 2+, occult blood 1+, glomerular excess rate decrease, it is recommended to consult the doctor in time regular hospitals, consulting the doctor can take the prophylactic injection and standardized treatment.