There is no such thing as what drugs lower aminotransferases with the best effect. The drugs that lower aminotransferases include hepatocyte membrane protectants, anti-inflammatory drugs, anticholestatic drugs, antioxidant drugs, and so on. 1. Hepatocyte membrane protection agent: with hepatoprotective effect, but also can inhibit steatosis and fibrosis, commonly used polyene phosphatidylcholine. It should not be used for children under 12 years old. 2. Anti-inflammatory drugs: diammonium glycyrrhizinate and magnesium isoglycyrrhizinate are commonly used drugs, which can be used for anti-inflammatory and hepatocyte membrane protection, and also have the effect of improving liver function. Severe hypokalemia and hypernatremia are contraindicated. 3. Anticholestatic drugs: ursodeoxycholic acid is commonly used, can make cholesterol stones gradually dissolve, the use of patients with acute cholecystitis need to pay attention to prohibited. 4. Antioxidant drugs: Reduced glutathione and silymarin are commonly used to protect liver synthesis, detoxification and inactivation of hormones. The above drugs should be used under the guidance of a doctor, and should not be used arbitrarily. Specific treatment program, need to be guided by a doctor, in order to better treat the disease.