Non-invasive generally refers to non-invasive DNA prenatal testing, which is generally tested at 12-22 weeks of pregnancy, usually done once during pregnancy, and is a detector test for the fetus in the womb. Non-invasive DNA prenatal testing requires the extraction of peripheral blood from pregnant women, sequencing of the free DNA in the blood, and biological analysis of the DNA sequences obtained, so that the genetic information of the fetus in the womb can be obtained, and to determine the presence of chromosomal disorders such as trisomy 13, trisomy 18, trisomy 21 and other chromosomal disorders. The prognosis of these disorders is not very good when they are treated, and they also have a great impact on the physical and mental development of the fetus, so when it is clear that the fetus has these disorders, it is possible to consider induced abortion to terminate the pregnancy. If the results of non-invasive DNA prenatal testing are normal, the patient should follow the doctor’s instructions to have regular checkups, and if the test results show a high risk, amniocentesis should be performed.