In response to the adverse reactions caused by intramuscular injection of progesterone, the reproductive department of our hospital conducted health education on early care intervention, emphasizing the importance of early care intervention; informed patients of the correct method of local self-care after injection, and issued an information sheet, instructing them to read it carefully and learn the method of self-care; when the injection was given again, the nurse first understood the patient’s implementation of early care intervention, and re-emphasized the importance of implementing the content of health education The nurses were told to read and learn the self-care method. I. Improvement of the injection method and precautions: The bubble-retention technique + Z-way + gradual depth of injection by changing directions at different times was chosen. The bubble retention injection method is to inject all the drug into the body at the end of the injection because of the residual air in the syringe, and when the needle is removed, there is no drug leakage to stimulate the tissues and skin, thus obviously reducing the patient’s pain. The gradual depth of injection by changing the direction at different times can make the drug enter between the muscle fibers of different injection sites at different times, so that even if the patient changes the position after the needle is removed, the muscle contraction at the injection site can almost avoid the extravasation of the drug. The injection interval should be extended as much as possible; the patient should be in a comfortable sitting or lateral position and in a relaxed state; the injection site should be chosen at the upper 1/4 of the outer buttocks, and both buttocks should be injected in alternate positions, avoiding red, swollen, hard nodes and scarred areas; according to the standard procedure of injection, the patient should choose a long needle of No. 7 or No. 8 for deep intramuscular injection according to the thickness of the fat in the buttocks; the injection should follow two fast and one slow (fast needle entry and extraction, slow drug pushing); injection After the injection, the patient was instructed to press the needle eye for 5~10 minutes. Second, the use of different methods of intervention: 1, wet hot compress + massage Chinese medicine theory that the formation of hard knots after intramuscular injection is due to obstruction of venous flow, qi stagnation and blood stasis, due to the injection of drug solution into the muscle, resulting in poor blood flow, over time, the formation of blood stasis and the formation of hard knots. Hot compress method for treating diseases has been recorded in China more than 2000 years ago, the “hot” method described in the “Yellow Emperor’s Classic of Internal Medicine” is the hot compress method. It uses heat to warm the meridians and channels, activating blood circulation and relieving pain. The specific method is 2~3 hours after injection, the towel will be dipped in 60~70 ℃ hot water (can also add 50% magnesium sulfate solution), wrung out and put on the affected area, every 3~5 minutes for 1 time, for 20~30 minutes, 3~4 times a day. Pay attention to 2~3 hours after the muscle injection, because the eye of the needle can only be closed after 2~3 hours, immediately hot compress easy to cause drug extravasation or microbial entry, causing itching, pain, redness and other inflammatory reactions. The water temperature should not be too high, so as not to burn the skin. After the hot compress massage with hands, clockwise and counterclockwise 50 times each, moderate strength, slow movement, 2 ~ 3 times a day. This method can relax the muscles, promote blood circulation, accelerate the absorption of the injection site, and play a role in reducing swelling and dissipating knots. The earlier the hot compress the better the effect. 2, potato compress the next morning after intramuscular injection using fresh potatoes washed and cut into thin slices of 1 ~ 2cm thick compress cover the muscle injection, fixed with gauze, can be covered with plastic wrap to keep the potatoes moist, potatoes change color when the replacement, 15-30min each time, 3-4 times a day, this is the test prescription, no potatoes can also be used as a substitute for fresh white radish. Can also be chopped fresh potatoes, add the right amount of vinegar mash into a puree, applied to the hard knots. Potatoes, also known as yams, are sweet and mild, tonifying the spleen and benefiting the qi, relieving pain and relieving anxiety, and are used externally to detoxify, disperse knots and reduce swelling. As early as the Tang dynasty “the compendium of materia medica” recorded: “raw research water to take. Detoxification of all drugs.” There are relevant data reported potato therapy for the treatment of muscle injection hard knots have a better effect, its efficiency is 96.4%. 3, moxibustion take a moxa strip, lit directly smoked hard node parts, the patient to feel a sense of warmth, comfort, in order not to feel the skin is very hot for the degree, these can be operated at home, easy to do. 4.Infrared local irradiation Infrared treatment mechanism is the thermal effect, and the penetration ability in the human body is limited, and is safe for pregnant women and fetuses. Under infrared irradiation, the tissue temperature increases, capillaries dilate, blood flow is accelerated, material metabolism is enhanced, and tissue cell vitality and regenerative capacity are increased. Infrared radiation improves blood circulation, increases the phagocytosis of cells, eliminates swelling, promotes the dissipation of inflammation, promotes local blood circulation, and decreases swelling of tissues. In addition, there are also reports in the literature: (1) Yunnan Baiyao: take a bottle of Yunnan Baiyao and mix it with white vinegar, pinch it into a thin cake and put it on the hard knot (the cake is slightly larger than the hard knot) and fix it for 2~3 days. (2)Cactus external: take a piece of cactus, remove the mango, pound it like mud, put it on the hard knot, cover it with gauze and fix it, once a day. (3) ice chips rubbing method: take 2~3 grams of ice chips, dissolve in 30 ml of 75% alcohol, after the ice chips dissolve, rub the hard knots with sterile gauze dipping solution, 5~10 minutes each time, once a day, often 3~5 days to see results. (4) rhubarb, mannitol external pack: rhubarb, mannitol 1:1 total finely ground froth, loaded into the gauze pack external.