Massive blood loss will lead to reduced renal blood supply, which can induce prerenal renal failure in severe cases. Massive blood loss will lead to insufficient blood volume in the body, reduced systemic circulating blood volume, decreased blood pressure, triggering sympathetic nerve excitation in the body, renal artery constriction to ensure the blood supply to other organs, reduced renal blood flow, reduced filtration, reduced urine output, and in severe cases, due to the reduction of renal blood flow leading to renal ischemia, affecting renal function, and even renal failure. Symptoms such as fainting, cold limbs, low urine output and irritability may occur with massive blood loss, and anuria and shock may occur if bleeding continues. Therefore, massive blood loss is a clinical emergency and requires urgent hemostasis and transfusion to correct the blood volume insufficiency and reduce the adverse effects on the organism. Therefore, it is necessary to consult a doctor immediately after massive blood loss, and follow the doctor’s instructions to actively rescue the treatment.