Genital herpes is a disease caused by herpes simplex virus infection. If acyclovir is not effective and tolerance may occur, you can switch to other antiviral drugs such as valacyclovir, famciclovir, and so on. The principles of genital herpes treatment are to shorten the course of the disease, prevent secondary bacterial infections, systemic dissemination, and reduce recurrence and transmission. General drug therapy, including systemic drug therapy, topical drug therapy. You can use vasiclovir, famciclovir and so on, the initial hair treatment course of 7 days to 10 days. If acyclovir is ineffective, possibly due to the emergence of drug resistance, it can be switched to vaxiclovir, famciclovir, and so on. At the same time, you can also use topical Penciclovir ointment, etc. for treatment. If genital herpes is diagnosed, do not self-medicate, you need to seek medical attention as soon as possible to avoid delays.