What is dmd progressive muscular dystrophy?

DMD progressive muscular dystrophy is an inherited muscular pathology disease that usually starts at age 3 to 4 years and most die around age 20 to 30. DMD, also known as Duchenne-type muscular dystrophy, is one of the nine types of progressive muscular dystrophy, pseudohypertrophic muscular dystrophy. DMD is an X-linked recessive disorder. Patients usually start the disease at the age of 3 to 5 years, with pelvic, low back and abdominal muscle weakness as the prominent symptom. Pseudohypertrophy of the muscles, which is tough to touch, is the first symptom, and is characterized by the Gower’s sign, in which the patient needs to turn from supine to prone, kneeling, and deep bowing to get up slowly. As the symptoms worsen, walking difficulties, myocardial damage, and smooth muscle damage in the gastrointestinal tract occur. Most patients die in their 20s to 30s due to heart failure and respiratory infections caused by atrophy of respiratory muscles. DMD can be diagnosed by clinical manifestations, genetics, and serum muscle enzymes and muscle biopsy. There is no cure, and symptomatic and supportive treatment, such as correction of spinal deformity and joint contracture, cardiopulmonary function monitoring, etc., is the mainstay of treatment. It is recommended that carriers of the DMD gene actively undergo prenatal diagnosis to prevent the birth of affected children.