The sudden appearance of yellow marks on the hands can not be washed off, considerations and physiological factors, pathological factors related. 1. Physiological factors: everyone’s eating habits are different, such as too much orange, pumpkin, carrots and other foods in daily life, may lead to yellowing of the hands or body, and washing with water usually can not be removed. It is recommended to reduce the intake of such food, with the passage of time, the yellowing of the hands can gradually reduce or disappear. 2. Pathological factors: yellowing of the hands can not be washed off, but also to understand whether it is related to pathological factors. For example, cholestasis or gallstones, bilirubin can not be excreted normally, may lead to yellow hands. The yellowing of the hands, which cannot be washed off, is usually considered to be related to the above factors. Physiological factors cause, usually do not need special treatment, suspected to be related to certain diseases, it is recommended to go to the hospital to find the cause.