Peptic ulcer, gastritis, reflux esophagitis and other diseases can cause acid reflux and heartburn symptoms, there is no absolute most effective drug, you can use omeprazole and other proton pump inhibitors, thioglycollate and other gastric mucous membrane protection agents. 1. Peptic ulcer: patients can use H₂ receptor antagonist (famotidine), proton pump inhibitors (omeprazole), gastric mucosa protection drugs (aluminum sulfate, teprenone) and other drugs for treatment. 2. Gastritis: Patients with gastritis can use drugs that inhibit or neutralize gastric acid, such as nizatidine and lansoprazole. Drugs such as bismuth potassium citrate and magnesium aluminum carbonate can protect the gastric mucosa. 3. Reflux esophagitis: it can be treated with drugs such as proton pump inhibitors (rabeprazole), H₂ receptor antagonists (ranitidine), and gastric stimulants (domperidone, mosapride). The above medications are recommended to be used under medical supervision. For symptoms of acid reflux and heartburn, it is recommended to go to the hospital promptly.