There can be up to 4 plus signs in a positive H. pylori result, the more plus signs the higher the number of infections, you should follow the doctor’s instructions for medication and anti-H. pylori treatment. H. pylori is a gram-negative bacillus, infection can cause gastritis, peptic ulcer, etc., and some patients will develop gastric cancer. H. pylori can be transmitted by fecal-oral route and oral-oral route. There are several clinical methods to detect H. pylori, such as endoscopic biopsy and urea breath test. If found positive for H. pylori, testing should be recommended for family members and their immediate population contacts. Patients should be treated with an oral quadruple anti-H. pylori regimen, specifically 2 antibiotics + proton pump inhibitor + bismuth, such as omeprazole, clarithromycin, amoxicillin, and bismuth pectin. If H. pylori is positive, the more the plus sign is, the more the number of infections is, it is recommended that the patient under the guidance of a specialized doctor to carry out standardized treatment, and finally, the medication should be used in accordance with the doctor’s instructions.