The best way to treat upstairs knee pain is to identify the cause of the disease and then treat it. The possible causes of upstairs knee pain are meniscus injury, osteoarthritis, traumatic arthritis and synovitis, etc., which need to be treated according to the different causes of the disease, and there are mainly medication and surgical treatment. 1. Meniscus injury: If the meniscus is injured, mild to moderate meniscus injury can be treated conservatively by using cast immobilization, avoiding usual activities, and at the same time using non-steroidal anti-inflammatory drugs for pain relief, such as celecoxib, ibuprofen and so on. For severe third-degree injuries, i.e. meniscus tear, arthroscopic meniscus suture or meniscoplasty is needed. 2. Arthritis: In the case of osteoarthritis and traumatic arthritis, symptoms are relieved by reducing exercise and conservative treatment. Patients with severe pain are treated with non-steroidal anti-inflammatory drugs such as celecoxib. If it has affected the patient’s daily work and life, it is necessary to consider surgery for artificial joint replacement. 3. Traumatic arthritis: cartilage defects can be caused by trauma and require medication such as glucosamine tablets. If the condition is serious, surgery is needed to repair the cartilage. 4. Synovitis: Synovitis of the knee joint can cause fluid retention in the knee joint, which can cause knee pain and restricted movement. It can be treated with joint puncture and intra-articular injection of hydroprednisone. Upstairs knee pain may also have other reasons, if the symptoms are not relieved, it is recommended to seek medical attention to identify the cause, under the guidance of the doctor for targeted treatment or treatment, the above drugs are recommended to be used under the guidance of a physician.