Glucose-lowering drugs that are not metabolized by the kidneys generally include insulin and insulin analogs. Insulin and insulin analogs are not metabolized by the kidneys and are suitable for diabetic patients with different degrees of renal function. When diabetes mellitus is combined with renal disease, the half-life of insulin is prolonged (i.e., the duration of action becomes longer), and it is necessary to reduce the dosage and pay attention to the occurrence of hypoglycemia. It should be noted that patients who are allergic to insulin are prohibited. In addition some oral hypoglycemic drugs with low renal excretion, such as Riglitazone, Rosiglitazone, Pioglitazone, etc. can also be used in patients with renal insufficiency. When diabetic patients with renal function abnormalities, they should choose the appropriate hypoglycemic drugs under the guidance of the doctor, and should not blindly use drugs on their own.