Lyme disease is a zoonotic infection due to spirochetes, commonly found in wandering erythema, with tick bites and blood sucking as the primary means of transmission. Lyme disease is generally caused by spirochete infection, which can be transmitted by insect vectors such as horseflies, mosquitoes, and many types of hard ticks, and there may be a risk of infection when entering grasslands and forests where ticks are active. Wandering erythema can be seen in the early stage of infection, and when erythema is not seen, there may be symptoms such as headache, malaise, fever, enlarged lymph nodes, muscle and joint pains, etc. With the development of the disease, it may cause neurological damages such as vomiting, headache, sleep disorders, chest tightness, shortness of breath, tachycardia, etc., as well as damages to the cardiovascular system, which can be treated with antibiotics such as Amoxicillin, Doxycycline and Cefixime. Patients who are bitten by ticks and experience uncomfortable symptoms should seek medical attention. Drugs need to be used under the guidance of a medical professional, and should not be used arbitrarily on their own.