There are many reasons for chest pain caused by coughing, such as pleural effusion, bronchitis, lung cancer, pneumonia, etc. It is necessary to make a clear diagnosis of the specific disease in order to get the best therapeutic effect on the treatment. 1. Pleural effusion: Infection of tuberculosis can cause pleural effusion, patients often have night sweats, chest pain and dry cough, in addition, inflammation exudate can also cause patients to cough and chest pain. Thoracic drainage can be used for treatment. 2. Bronchitis: upper respiratory tract infection can cause bronchitis, severe cough, bronchospasm, damage to the airway, there may be different degrees of chest pain. Treatment needs to control infection, suppress cough and expectorant synchronous treatment. Commonly used antibacterial drugs include ceftriaxone and azithromycin, etc. Expectorant drugs commonly used are aminoglutethimide and acetylcysteine. 3. Lung cancer: irritating dry cough can be seen in early stage, and when the tumor invades the chest wall, it leads to chest pain. It can be aggravated when breathing and coughing. It needs timely surgical treatment with radiotherapy. 4. Pneumonia: cough and inflammatory exudation are often seen in pneumonia, and when the condition is aggravated, bloody sputum can be seen in airway damage, leading to chest pain. Need to clarify the causative agent after anti-infection treatment, commonly used antibacterial drugs are ceftriaxone, piperacillin sodium tazobactam sodium, azithromycin and so on. There are many causes of chest pain after coughing, it is recommended that patients go to the hospital in time to clarify the cause of the disease, and treatment under the guidance of the doctor. The above drugs should be used under the guidance of a doctor.