Amlodipine benzenesulfonate and angiotensin II receptor antagonists, such as valsartan, are better used in combination, and they have complementary effects. Amlodipine benzenesulfonate belongs to the calcium antagonist, its antihypertensive effect is mainly realized by blocking calcium channels, dilating the blood vessels of the heart, brain and kidney. Angiotensin II receptor antagonist is mainly through the dilatation of peripheral veins, regulating capillary venous pressure to achieve. The two have different mechanisms of action, there are complementary, can better play the function of antihypertensive. At present, there are many kinds of antihypertensive drugs applied in the clinic, but the mechanism of action is different, the patient should choose different kinds of antihypertensive drugs with the advice of the doctor, do not take the drug and stop taking the drug on their own.