Coffee is best not to drink on an empty stomach, coffee contains a large amount of caffeine, may stimulate the stomach and intestines, and has individual differences. Coffee has a refreshing effect, but it contains a large amount of caffeine, due to individual physical differences or drinking too much, some people drink on an empty stomach will stimulate the gastrointestinal tract, resulting in damage to the gastric mucosa, but also may stimulate the glands of the stomach, resulting in an increase in the secretion of digestive juices such as gastric acid and pepsin, which is prone to gastric discomfort, such as gastric pain, gastric ulcers. Coffee is not recommended for patients who have gastrointestinal disorders themselves, and may aggravate the condition. In addition, coffee also excites the cerebral cortex, which may have an adverse effect on sleep, and is not recommended for people with sleep disorders. As a common drink in modern life, coffee can be consumed in moderation, try not to drink it on an empty stomach, and it is recommended to consume it with other foods.