Uric acid is a product of purine metabolism in the body, and may be produced more due to diet, disease, or abnormal metabolism, or reduced uric acid excretion due to kidney factors, resulting in the formation of crystalline deposits of uric acid salts and high uric acid at the time of examination. Occasional high uric acid can be related to lifestyle, while long-term high values require medical attention. Common clinical factors that cause high uric acid include increased uric acid production and decreased excretion: 1. Increased uric acid production: 1. External factors: after strenuous exercise, it can lead to a large number of skeletal muscle adenine nucleoside triphosphate decomposition, causing an increase in uric acid; it can also be related to high purine diet, excessive alcohol intake, high sugar diet, common high purine food including animal liver, kidney, anchovies, etc.; 2. Myocardial infarction, acute respiratory failure, etc. can cause accelerated decomposition of adenine nucleoside triphosphate, producing a large amount of purine; 3, congenital factors: some patients are affected by genetics, resulting in abnormalities in the body enzymes, unable to metabolize purine normally, which can lead to high uric acid. 2. Reduced uric acid excretion: 1. Dietary factors: The intake of fructose- and glucose-rich beverages leads to a decrease in uric acid excretion due to the co-transportation of uric acid and sugar by renal tubular cells. Alcohol can increase the production of uric acid and reduce the excretion of uric acid; 2, disease factors: such as renal insufficiency, renal tubular disease, etc., can cause a decrease in uric acid excretion and increase the blood uric acid; 3, drug factors: long-term use of hydrochlorothiazide, furosemide and other diuretics, pyrazinamide, isoniazid and other anti-tuberculosis drugs, anti-Parkinson’s disease drugs, and aspirin, etc., may lead to a decrease in uric acid excretion, causing High uric acid. In addition, obesity, chronic diarrhea, long-term hypertension, hyperlipidemia, diabetes, and arteriosclerosis are all risk factors for high uric acid, so clear examination and timely symptomatic treatment should be carried out when abnormal indicators appear.