Cardiac discomfort accompanied by vomiting is mainly found in two cases: the first is when the primary disease is heart disease and vomiting is a concomitant symptom of heart disease, most commonly myocardial ischemic lesions, for which electrocardiogram and myocardial enzyme tests are recommended; if there is significant myocardial ischemic damage, ischemia improvement and anti-anginal therapy are required. In the second case, the primary disease is gastrointestinal disease and cardiac discomfort is a concomitant symptom of gastrointestinal disease, most commonly cholecystitis or other acute gastroenteritis, resulting in reflex cardiac pain and tachycardia, which generally requires effective anti-infection treatment for the location of the infection. To avoid misdiagnosis and omission, routine electrocardiogram is required to assist in the diagnosis even if gastrointestinal disease is considered.