The causes of numbness and pain in feet and toes during chemotherapy for endometrial cancer include side effects of chemotherapeutic drugs, embolism of blood vessels in legs and feet, or bone metastasis of toes caused by cancer lesions. 1. Endometrial cancer often chooses paclitaxel type of drugs to carry out chemotherapy, this kind of chemotherapeutic drugs will often cause peripheral nerve toxicity side effects, and numbness of hands and feet, pain and other symptoms often appear in the clinic, so methylcobalamin, vitamin B and other drugs can be chosen to nourish the nerves and relieve numbness and pain. 2. Patients with endometrial cancer often have high blood viscosity, so it is easy for them to develop venous thrombosis and other complications in legs and feet, which may cause numbness and pain in feet and toes. 3. Patients who are resistant to chemotherapy and have disease progression during chemotherapy may also have symptoms of toe pain and numbness due to metastasis in toe bones. It is recommended that patients consult the doctor in a timely manner, improve the relevant examination to clarify the cause, and actively treat the disease to avoid delays.