There are many diseases that can cause weakness of the limbs and weakness of the legs and feet in female patients. Some of the more common causes include fever from various causes, electrolyte disorders such as hypokalemia, hyponatremia or hypocalcemia. In addition, there are abnormalities in blood sugar, especially in patients with hypoglycemia, patients will experience weakness in the limbs and weakness in the legs and feet, often accompanied by panic, sweating and other discomforts, and blood glucose measurement can be a clear diagnosis. Abnormal thyroid function can also cause weakness, such as hyperthyroidism, which can be diagnosed by triple A tests. Therefore, it is recommended that patients with weakness in the extremities should go to the hospital in a timely manner to improve blood tests, electrolytes, blood glucose and triple A tests, and monitor body temperature and blood pressure to find the cause. If necessary, other rare diseases, such as Green-Barre syndrome, motor neuron disease, and myasthenia gravis, should also be excluded.