Prolonged use of povidone-iodine may lead to the following hazards: skin damage, dysbiosis and so on. Povidone-iodine has a strong oxidizing effect, with oxidizing and disinfecting effect, if used for a long period of time, it may lead to damage to the stratum corneum of the skin, which will lead to a reduction of the barrier function of the skin. Because povidone-iodine is an oxidizing agent, after long-term application, it can kill the local pathogenic bacteria, but it will also kill the normal bacteria, and after the normal bacteria are killed, it will lead to bacterial imbalance, which can cause secondary infections, such as fungal infections and so on. After the skin or mucous membrane has been broken, it is necessary to disinfect the local area, and it is recommended to choose the disinfectant under the guidance of the doctor, such as iodophor, alcohol and so on.