Ibuprofen and colchicine can be taken together after excluding the contraindications of the corresponding drugs. Ibuprofen is a non-steroidal anti-inflammatory drug, colchicine is an alkaloid, both can be used to relieve the symptoms of acute attacks of gout, the simultaneous use of can play a better effect of pain, but there are contraindications to the two drugs should not be used in the treatment of ibuprofen and colchicine, which should be taken colchicine should pay extra attention to the amount of drug administration to avoid overdose. Common adverse drug reactions to ibuprofen include gastrointestinal discomfort, nausea, rash, and itching. Colchicine adverse reactions include gastrointestinal discomfort, muscle and peripheral neuropathy, myelosuppression, shock, etc. Patients with colchicine adverse drug reactions should reduce the dose of the drug administered, and in severe cases, should be discontinued. Ibuprofen is contraindicated in people who are allergic to the drug, allergic to other non-steroidal drugs. Colchicine is contraindicated in myelodysplasia and in hepatic and renal insufficiency. Note that ibuprofen should be avoided in conjunction with other non-steroidal anti-inflammatory drugs, and long-term users need to pay attention to the symptoms of gastrointestinal bleeding. Liver and kidney function and blood picture should be checked regularly during the use of colchicine. Ibuprofen and colchicine should be used under the guidance of a physician, it is recommended that patients who need to take ibuprofen and colchicine to the relevant departments of the regular hospital for detailed consultation, do not take the drug on their own.