Large blisters caused by liquid nitrogen freezing will generally heal on their own if the blisters do not break down and become infected. Liquid nitrogen freezing is the use of liquid nitrogen ultra-low temperature so that the local tissue cell necrosis, treatment may cause skin damage blisters, is a normal phenomenon, the general situation will be self-healing, twenty days or so will be naturally scabbed off. If the blisters break down and become infected after treatment, anti-infection treatment is required under the guidance of a doctor, such as topical erythromycin and other antibiotic creams. Liquid nitrogen freezing caused by large blisters do not need to worry too much, daily life to avoid friction or collision to the blisters, so as to avoid blisters rupture secondary infection, such as large blisters affecting the life or rupture secondary infection, it is recommended to go to a regular hospital, under the guidance of the doctor treatment.