Perforation of the eardrum generally refers to tympanic membrane perforation, tympanic membrane perforation with ear drops after the special pain, may be the drum chamber mucosa nerve sensitivity is high, the drug component stimulation caused by the first need to suspend the use of ear drops. And according to the secretion bacterial culture, replace the drug medicine. If the patient after the use of ear drops appeared local abnormal pain, first of all, it is recommended to first suspend the use of ear drops. If it is otitis media perforation, you can replace the non-toxic antibiotic ear drops, such as flucloxacin ear drops, rifampicin ear drops, etc., and also use broad-spectrum antibiotic drugs, such as amoxicillin, cefuroxime, etc., as appropriate. If the tympanic membrane perforation belongs to traumatic general disease can be self-healing, no need to take special treatment measures. However, if the perforation is large, or there is no sign of healing for a long time, tympanoplasty is needed to repair the tympanic membrane. Some patients with intolerable pain can take oral non-steroidal anti-inflammatory drugs, such as ibuprofen and acetaminophen, under the guidance of a doctor. Patients with tympanic membrane perforation who experience severe earache and pain should go to a regular hospital, identify the cause of the disease, and then actively take standardized medication and treatment.