Before receiving the HPV vaccine, patients need to undergo relevant medical checkups, and the checkups that patients need to undergo are mainly the following: First, screening for HPV in women is needed to observe whether patients have human papillomavirus infection. Because the HPV vaccine contains very few types of HPV infections that can be prevented, patients should be examined before the vaccine is administered, and if they have HPV infections, they need to be treated and followed up regularly even after the vaccine is administered. Second, women of childbearing age must undergo pregnancy-related screening before receiving the HPV vaccine. After ruling out pregnancy, it is also important to use good contraception during the HPV vaccination period. If pregnancy is found, HPV vaccination should be stopped immediately and the remaining HPV vaccine should be administered after the birth is over. Third, the HPV vaccine should be tested for blood pressure, pulse, and temperature before injection, and the HPV vaccine should not be administered if the patient has serious medical conditions or is in the acute infection period.