Severe weak sperm is considered to be 2% of weak sperm, patients need to follow the doctor’s instructions for drug treatment, surgical treatment, assisted reproduction and so on. 1. Drug treatment: usually for endocrine abnormalities caused by weak spermatozoa, patients need to be given human chorionic gonadotropin and other treatments, for hyperprolactinemia caused by weak spermatozoa, you can use bromocriptine and other dopamine agonists treatment. If it is caused by inflammation such as epididymitis, orchitis, etc., antibacterial drugs such as cefuroxime, levofloxacin, etc. should be used to treat the inflammation. At the same time, patients can also use drugs such as levocanidin to improve the energy metabolism of spermatozoa. Some patients can also be treated with medications to improve microcirculation such as hepcidin and pancreatic kininogenase. All the above drugs need to pay attention to the side effects and adverse reactions of the drugs, please use the above drugs under the guidance of the doctor. 2. Surgery: If the patient is suffering from varicocele, the patient should follow the doctor’s instruction to carry out high ligation of the internal vein of spermatic cord, and if the infertility is caused by the systemic disease, the patient should carry out the corresponding systemic surgery, such as surgery of thyroid gland, pituitary tumor surgery, and so on. 3. Assisted Reproduction: If the above treatments are not effective, conception can also be achieved through assisted reproductive techniques such as in vitro fertilization. It is recommended that patients with a degree of weak sperm 2% of the case, according to their own situation, under the guidance of the doctor to carry out targeted treatment, so as to avoid aggravation of the condition.