Nimesulide granules are a non-steroidal anti-inflammatory drug that has some pain-relieving effect in addition to its fever-reducing effect. Therefore, it can be used in the absence of fever if pain relief is needed. However, Nimesulide granules are not usually used as the first choice for fever and pain relief, but are usually considered when other NSAIDs fail, for example, for pain relief in osteoarthritis pain, or pain relief in acute trauma and after surgery, and for pain relief in menstrual cramps. Nimesulide granules may cause acid reflux, heartburn, nausea and other symptoms in the stomach, and may cause allergic rash, Nimesulide granules should not be used for pain relief of angina pectoris in patients with coronary artery disease.