High total bile acids after chemotherapy are usually caused by impaired liver function, obstruction of the biliary system, endocrine abnormalities and other diseases. The details are as follows: 1. Impaired liver function: the metabolic function of the liver decreases, the synthesis and decomposition of bile acids decreases, causing the accumulation of bile acids in the blood, which results in high total bile acids. 2. Biliary system obstruction: patients with intrahepatic bile stagnation and extrahepatic bile duct obstruction, bile acid can not be discharged into the small intestine, but into the blood vessels, resulting in high total bile acid in the blood. 3. Endocrine abnormality: excessive secretion of thyroid hormone in the patient’s body will accelerate the metabolism of cholesterol in the body, so that more cholesterol will be converted into bile acids, resulting in high total bile acids. It is recommended that patients with high total bile acid should go to regular hospitals to find out the cause of high total bile acid, and take appropriate treatment according to their own conditions, so as to avoid delaying the condition.