Sildenafil can be taken with cold water. Sildenafil is a type 5 phosphodiesterase inhibitor and is mainly used to treat erectile dysfunction. The instructions for use do not specify whether it should be taken with warm or cold water, and no studies have found that taking it with cold water affects its efficacy, so sildenafil can generally be taken with cold water. Adverse reactions such as headache, facial flushing, dyspepsia, nasal congestion, dizziness, visual abnormalities, back pain, and muscle pain may occur after taking the drug. In addition, organic nitrates such as nitroglycerin, isosorbide mononitrate, isosorbide nitrate, etc. can cause intractable hypotension when used in combination with sildenafil, therefore, the combination of the two is absolutely prohibited. In addition, the drug is also prohibited for women, people who are allergic to the product, children and other people. If you need to use related drugs, please use under the guidance of a specialist physician physician or pharmacist; after the use of the symptoms of discomfort, please consult a doctor in a timely manner, active treatment, in order to avoid delaying the condition.