Patients with darkness around the mouth first need to have their liver function checked to see if they have elevated glutamic and glutamic aminotransferases and elevated bilirubin. This is most often seen in patients with a combination of hepatitis, either viral or other hepatitis, such as autoimmune hepatitis, alcoholic hepatitis, or drug-related hepatitis. In such cases, the patient needs to be further investigated to see the specific cause of the hepatitis and further treatment will be given according to the cause. If the patient has viral hepatitis, the type of hepatitis and whether the patient has viral replication should be investigated further. If there is viral replication, combined with liver function damage, we should actively consider antiviral treatment. Secondly, for some patients, due to the lack of trace elements and the patient’s poor night rest, the patient may also have the situation of darkness around the mouth. For such cases, patients should pay attention to timely rest, do not stay up late, do not strain. In addition, pay attention to more rest at night, the appropriate amount of oral intake of a variety of trace elements, the patient will slowly get better in this situation.