The treatment of patients with lacunar cerebral infarction in both basal ganglia areas mainly consists of oral aspirin against platelet aggregation. If patients are intolerant to aspirin, clopidogrel can also be used. At the same time, improving blood circulation can be given, and commonly used drugs include sulforaphane, vincristine, and trimethoprim, and sparing blood can also be applied. Neuroprotective therapy is actively given, and commonly used drugs include edaravone, cytarabine, cerebroprotein hydrolysate, olanzapine, piracetam, and vincristine can also be applied. Butalbital can also be applied to improve the signs and symptoms of neurological deficits if the patient’s somatic signs and symptoms are severe, and cranial pressure-lowering therapy is generally not required. It is also important to give control of the etiology, and common causes of lacunar cerebral infarction include hypertension and diabetes mellitus. Patients with hypertension can be treated with oral amlodipine, amlodipine besylate and irbesartan to lower blood pressure; patients with hyperglycemia are generally preferred to take metformin orally. If the patient’s blood glucose control is poor, subcutaneous insulin injection can also be used for glucose-lowering treatment.